Articles, Presentations, and Publications

Publications and Essays on IPT

Insulin Potentiation Therapy: A Renaissance in Cancer Chemotherapy – How Does it Work? S.G. Ayre, MD

The Physiology and Clinical Pharmacology of Insulin in Relation to its Application in Insulin Potentiation Therapy – Steven G. Ayre MD

Poster Presentation at the Third Annual Comprehensive Cancer Management Conference, Washington DC, June 2000

Hoist By One’s Own Petard. S. G. Ayre, Townsend Letter, Oct. 1999.

Insulin Shows Promise. Oncology News, 1991, 17(4): 1,7

International Congress on Neo-Adjuvant Chemotherapy – Paris 1991

Neoadjuvant Low-Dose Chemotherapy with Insulin in Breast Carcinomas: S.G. Ayre, Perez-Garcia y Bellon, Perez-Garcia, Jr. European Journal of Cancer. 1990. 26(11-12): 1262-3.

Blood Brain Barrier Passage of Azidothyumidine in Rats: Effects of Insulin – S.G. Ayre, B. Skaletski, A.D. Mosnaim. Research Communications in Chemical Pathology and Pharmacology. Jan. 1989. Vol. 63, No. 1.

New Approaches to Delivery of Drugs to the Brain: S.G. Ayre. Medical Hypotheses 29:283-291, 1989.

IPT: A New Concept in the Management of Chronic Degenerative Disease: S.G. Ayre, D Perez Garcia y Bellon, D. Perez Garcia, Jr. Medical Hypotheses. 20(2): 199-210, 1986.

Insulin, chemotherapy, and the mechanisms of malignancy: the design and the demise of cancer. Ayre, Steven G., and D. P. Bellon. Medical hypotheses 55.4 (2000): 330-334.

Ayre, S. (May 2001). Insulin Potentiation Therapy (IPT): A Renaissance in Cancer Chemotherapy. Annual Spring Conference of the American College for Advancement of Medicine. Lecture conducted from Nashville, TN. 

Low dose chemotherapy in combination with insulin for the treatment of metastatic tumors: C. Damyanov, M. Radoslavova, V. Gavrilov, D. Stoeva. Medical Center of Integrative Medicine, Sofia, Bulgaria. Journal of BUON 14: 711-15, 2009.

Insulin Potentiation Therapy in the treatment of malignant neoplastic diseases: a three year study. Damyanov C, Gherasimova DM, Avramov LA, Masley IK (2012). J Cancer Sci Ther 4: 088-091. doi:10.4172/1948-5956.1000117

Low-Dose Chemotherapy with insulin (Insulin Potentiation Therapy) in combination with hormone therapy for treatment of castration-resistant prostate cancer. Damyanov, Christo, et al. ISRN urology 2012 (2012).

Long-Term Outcomes of the Treatment of Unresectable (Stage III-IV) Ductal Pancreatic Adenocarcinoma Using Metabolically Supported Chemotherapy (MSCT): A Retrospective Study. Iyikesici, Mehmet Salih, et al. JOP. Journal of the Pancreas (2016).

Complete Response of Locally Advanced (stage III) Rectal Cancer to Metabolically Supported Chemoradiotherapy with Hyperthermia. Iyikesici MS, Slocum A, Turkmen E, Akdemir O, Slocum AK, et al. (2016) Int J Cancer Res Mol Mech 2(1): doi

Efficacy of Metabolically Supported Chemotherapy Combined with Ketogenic Diet, Hyperthermia, and Hyperbaric Oxygen Therapy for Stage IV Triple Negative Breast Cancer. İyikesici, M. S., Slocum, A. K., Slocum, A., Berkarda, F. B., Kalamian, M., & Seyfried, T. N. (2017). Cureus9(7).

Liu, Y., Zhang, Y., Mao, X., Qi, Q., Zhu, M., Zhang, C., … & Ling, Y. (2017). Palliative treatment efficacy of glucose inhibition combined with chemotherapy for non‑small cell lung cancer with widespread bone and brain metastases: A case report. Biomedical reports7(6), 553-557.

Feasibility study of metabolically supported chemotherapy with weekly carboplatin/paclitaxel combined with ketogenic diet, hyperthermia and hyperbaric oxygen therapy in metastatic non-small cell lung cancer. Int JnHyperthermia. 2019;36(1):446-455.

Long-Term Survival Outcomes of Metabolically Supported Chemotherapy with Gemcitabine-Based or FOLFIRINOX Regimen Combined with Ketogenic Diet, Hyperthermia, and Hyperbaric Oxygen Therapy in Metastatic Pancreatic Cancer. Complement Med Res. 2020;27(1):31-39.

Supportive Studies – Published clinical and in-vitro studies that support the use of  insulin as a biologic response modifier.

Agrawal, S., Woźniak, M., Łuc, M., Makuch, S., Pielka, E., Agrawal, A. K., … & Ziółkowski, P. (2019). Insulin enhancement of the antitumor activity of chemotherapeutic agents in colorectal cancer is linked with downregulating PIK3CA and GRB2. Scientific reports9(1), 1-14.

Insulin-induced enhancement of MCF-7 breast cancer cell response to 5-fluorouracil and cyclophosphamide. Agrawal, Siddarth, et al. Tumor Biology 39.6 (2017): 1010428317702901.

Metabolic Modification by Insulin Enhances Methotrexate Cytotoxicity in MCF-7 Human Breast Cells. Alabaster, O. Vonderhaar, B. and Shafie, S. Eur J Cancer Clin Oncol. Vol 17, No. 11, pp 1223-1228. 1961. 

Insulin treatment in cancer cachexia: effects on survival, metabolism, and physical functioning. Lundholm K, Körner U, Gunnebo L, Sixt-Ammilon P, Fouladiun M, Daneryd P, Bosaeus I. Clin Cancer Res. 2007 May 1;13(9):2699 706.

Long-Term Effect of Diabetes and Its Treatment on Cognitive Function. Jacobson, Alan, N Engl J Med 2007; 356:1842-52.

Preclinical safety and antitumor efficacy of insulin combined with irradiation. Bénédicte F. Jordan, Nelson Beghein, Nathalie Crokart, Christine Baudelet, Vincent Gregoire, Bernard Gallez. Radiotherapy and Oncology 81 (2006) 112–117.

Insulin-induced enhancement of antitumoral response to methotrexate in breast cancer patients. Lasalvio-Prisco, Eduardo, Cancer Chemother Pharmacol (2004) 53: 220–224.

The effect of insulin on chemotherapeutic drug sensitivity in human esophageal and lung cancer cells. Zhonghua Yi Xue Za Zhi. 2003 Feb 10;83(3):195-7. 

Pretreatment with insulin enhances anticancer functions of 5-fluorouracil in human esophageal and colonic cancer cells. Zou K, Ju JH, Xie H. Acta Pharmacol Sin. 2007 May; 28(5):721-30. 

A pilot study of Auron Misheil Therapy (AMT) in patients with advanced cervical cancer: tumor response and its correlation with clinical benefit response, and preliminary quality of life data.” Scheele, Jürgen, et al. Oncology reports 22.4 (2009): 877-883.

Insulin in endometrial carcinoma chemotherapy: A beneficial addition and not a problem. Sha, Huilan, et al. Journal of Huazhong University of Science and Technology [Medical Sciences] 30 (2010): 631-637.

Periodical Publications on Dr. Ayre and IPT

Chicago Magazine. The New Docs. January 2005.

A New Approach to Cancer Care – Middendorf, Bobbye. Conscious Choice. April 2001, Vol. 14 No. 4, 28-29.

Chitwood finds strength in physician’s alternatives. Kendra L. Williams. Downers Grove Progress. Sept. 22, 2000.

Doctor to practice alternative methods for treating cancer – Kenneth Patchen. Antioch News. July 31, 1997. P A7.

Local Doctor develops treatments for cancer – Brian Murphy. Tom Tom (newspaper of Antioch Community High School, Antioch, IL). May 24, 1996

Doctor Researches Lifesaving Applications for an old drug. Mary Catherine Rhedin. Lakeland Newspapers, December 7, 1990. Pp 13-14.

Hypoglycemia: The Hidden Danger. Bill Christopher. Zion News, 1983. 

History of IPT

Chronology of Events in the Scientific Evaluation and Development of IPT – October 1989 – December 2005

Documents of Historical Interest

FDA Drug Bulletin, April 1982

Personal Essays from Dr. Ayre

Managing Malignancy: Our Answer to Cancer 

My Medical Opinion

Developing a Spirit of Achievement

Healing Ourselves


Psychoneuroimmunology and the Future of Medicine. S.G. Ayre, Townsend Letter, Nov. 1988.

Let’s Do Part to Cure Ills of Society. S.G. Ayre, American Medical News, Feb. 17, 1989.

MDs Must be Participants in Evolution of Medicine. S.G. Ayre, American Medical News, March 25, 1988.

Science Must Embrace Human Need. S.G. Ayre, American Medical News.

Too Bad Society Not Ready for Ideals. S. G. Ayre, American Medical News, Nov. 27, 1987.