Education and training
1966 – McGill University, B.A. (philosophy & mathematics)
1967 – University of Ottawa, Pre-Med. Dean’s Honor List
1971 – University of Ottawa Medical School. M. D.
1971-72 – Rotating internship at the Royal Victoria Hospital in Montreal, Canada
Clinical, research, and community service experience
1972-82 – Private practice of Family Medicine at the Ayre Medical Clinic in the Town of Mount Royal, Quebec. This was a community based group practice where I worked in partnership with my father, W. Burton Ayre, M.D.
1982-84 – Private practice of Family Medicine in Zion, Illinois. Admitting privileges at American International Hospital. Practiced complementary, nutritionally-oriented medicine – hypoglycemia, chronic candidiasis, chronic fatigue syndrome, allergies.
1984 to 1997 – Private practice of Family Medicine with Primary Care Family Centers, S.C., in Libertyville, Illinois. Admitting privileges at St. Therese Hospital in Waukegan, and Condell Memorial Hospital in Libertyville, Illinois.
1997 to Feb. 1998 – Practice of Complementary and Alternative Medicine at the Kingsley Medical Center, Arlington Heights, Illinois.
1998-1999 – Practice of Complementary and Alternative Medicine at the Waveland Wellness Center, Chicago, Illinois.
March – October 1999 – General practice of medicine as staff physician at Life Care Systems, Aurora, Illinois.
November 1999 to present – Private practice of Family Medicine in Burr Ridge, Illinois.
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1973-82 – Medical Director of the Montreal Association for Children with Learning Disabilities. 1982 – Emigrated to the United States.
1986 to present – Clinical Assistant Professor in the Department of Family Medicine at the University of Health Sciences/the Chicago Medical School.
1985 to 1987 – Secretary of the Lake County Tuberculosis Board.
1987 to present – President of the Lake County Tuberculosis Board.
1988 – Member of the Lake County Medical Society’s Liaison Committee with The University Health Sciences/the Chicago Medical School.
1987 to 1990 – Member of the speaker’s bureau at the Howard Brown Memorial Clinic in Chicago (AIDS education).
1988 – Initiated a research project supported by the Burroughs-Wellcome Company at the UHS/CMS, Department of Pharmacology, investigating the effect of exogenous insulin on the transport of AZT across the blood-brain barrier.
1987, 1988 and 1989 – Attendee at the III, 1V and V International Conferences on AIDS in Washington, D.C., Stockholm, Sweden, and Montreal, Canada.
Published Articles
Ayre SG, Perez Garcia y Bellon D, Perez Garcia Jr D. Insulin potentiation therapy: a new concept in the management of chronic degenerative disease. Med Hypotheses 20(2) :199-210, 1986.
Ayre SG, Skaletski B, Mosnaim AD. Blood-brain barrier passage of azidothymidine in rats: effect of insulin. Res Commun Chem Pathol Pharmacol 63(1):45-52, 1989 .
Ayre SG. New approaches to the delivery of drugs to the brain. Medical Hypotheses 29: 283-291, 1989.
Ayre SG, Perez Garcia y Bellon D, Perez Garcia Jr D. Neoadjuvant low-dose chemotherapy with insulin in breast carcinomas. Eur J Cancer, 26, 1262-1263, 1990 .
Ayre SG, Perez Garcia y Bellon D, Perez Garcia Jr D. Insulin, Chemotherapy, and the Mechanisms of Malignancy: the design and the demise of cancer. Article accepted for publication in Medical Hypotheses, 2000.
Lectures and Poster Presentations
Ayre SG. Donatian Therapy: a new concept in the management of chronic degenerative disease. Presented at the Spring Conference of the International Academy of Preventive Medicine, Dallas, February 25, 1981.
Ayre SG. New approaches to the delivery of drugs to the brain. Presented to the members and graduate faculty of the Department of Pharmacology, University of Health Sciences/the Chicago Medical School, December 9, 1987.
Ayre SG, Skaletski B, Mosnaim AD. The blood-brain barrier passage of azidothymidine in rats: effect of insulin. Poster presentation at the Ninetieth Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics, Nashville, Tennessee, March 8-10, 1989.
Ayre SG, Skaletski B, Mosnaim AD. Enhancement of antiviral therapy in HIV infection using blood-brain barrier (BBB) modification with insulin: animal data and clinical considerations. Poster presentation at the V International Conference on AIDS, Montreal, Canada, June 4-9, 1989.
Ayre SG, Perez Garcia y Bellon D, Perez Garcia Jr D. Breast carcinoma treated by a regimen of low-dose chemotherapy and insulin: report of four cases and pharmacokinetic considerations. Poster presentation at the Forty-second Annual .Symposium on Fundamental Cancer Research, The University of Texas, M.D. Anderson Cancer Center. October 24-27, 1989.
Ayre SG, Neoadjuvant Chemotherapy for the Treatment of Cancers of the Breast. Presentation to the Tumor Board of Condell Memorial Hospital, Libertyville. Illinois, September 14, 1990. Ayre SG, Perez Garcia y Bellon D, Perez Garcia Jr D. Insulin plus low-dose CMF as neoadjuvant chemohormonal therapy for breast carcinoma. Oral presentation at the Third International Congress on Neoadjuvant Chemotherapy, Paris, France, February 6-9, 1991.
Ayre SG. Presentation entitled “Insulin Potentiation Therapy – Best Case Series Approach” given at the National Institutes of Health conference on Practice Outcomes Monitoring and Evaluation System (POMES) jointly sponsored by the Office of Alternative Medicine (OAM) and the National Cancer Institute (NCI) in Bethesda, Maryland, August 4-6,1997
Ayre SG. Primary Breast Preserving Treatment for Breast Cancer Using Biologic Response Modification with Insulin in Combination with Non-Toxic Low-Dose Chemotherapy. Poster presentation at the Third Annual Comprehensive Cancer Management Conference in Washington, D.C., June 9-11, 2000
Ayre SG. Insulin Potentiation Therapy: A Renaissance in Cancer Chemotherapy. Oral presentation at the Fall Conference of the Great Lakes College of Clinical Medicine in Pittsburgh, PA, on September 16, 2000.
Ayre SG. Insulin Potentiation Therapy: A Renaissance in Cancer Chemotherapy. Oral presentation at the Spring Conference of the International Oxidative Medicine Association in Las Vegas, NV, on February 23, 2001.
Ayre SG. Insulin Potentiation Therapy: A Renaissance in Cancer Chemotherapy. Oral presentation at the Spring Conference of the American College for Advancement in Medicine in Nashville, TN, on May 11, 2001.
Ayre, SG. Primary Breast Conserving Treatment for Breast Cancer using Biologic Response Modification with Insulin in Combination with Non-toxic Low-Dose Chemotherapy. Poster presentation at the Midwest Clinical Conference of the Chicago Medical Society, Chicago, IL, March 23-25, 2002. This poster presentation was recognized as one of the five best presentations made.
Research Activities
IND submission and acceptance of a protocol entitled “Insulin as a Pharmacologic Adjunct to Zydovudine (ZDV) in the Treatment of Symptomatic HIV Infection (CDC Group IV).
IND submission to the FDA for a protocol entitled “Neoadjuvant Combination Chemohormonal Therapy for Carcinomas of the Breast using low-dose CMF plus insulin”.
Submission of a “Best Case Series” of the clinical results obtained with IPT made to the Cancer Treatment Evaluation Program (CTEP) of the National Cancer Institute (NCI). August 1992.
Phase I and Phase II studies investigating the IPT concept at the Xuzhou Medical College Cancer Center in Xuzhou, China. April – June 1994.
Personal visit to Xuzhou Medical College Cancer Center in July 1994 to discuss and clarify elements of the IPT protocol for the ongoing work at this institution.
Animal study to investigate the pharmacokinetics of IPT undertaken at the Georgetown University Medical Center in Washington, D.C. Funding for this study received from the Cancer Treatment Research Foundation, affiliated with the Cancer Treatment Centers of America.
Protocol for a multi center prospective clinical trial of IPT in the treatment of stage IV cancers of the breast, lung, and ovary submitted to, and approved by, the Institutional Review Board of the Great Lakes College of Clinical Medicine at their fall meeting – September 16 – 20, 1997, in Pittsburgh, PA.
Presentation of a Best Case Series (BCS) on the clinical results of Insulin Potentiation Therapy in the management of malignancy before the members of the Cancer Advisory Panel of the Center for Complementary and Alternative Medicine at the National Institutes of Health in Bethesda, Maryland, on September 18, 2000.
Notification from Dr. Jeffrey White, Director of the Office of Cancer Complementary and Alternative Medicine (OCCAM) of a Broad Agency Announcement (BAA) designed to facilitate comprehensive study of Best Case Series (BCS) qualified Complementary and Alternative (CAM) cancer submissions. IPT is one such CAM cancer therapy to successfully pass through the BCS process. Correspondence re BAA received Dec 15, 2005. Application submitted March 20, 2006.
Received notification of denial from OCCAM April 2007. Application deemed unacceptable for “technical reasons.”
Jeffry D. White, MD, Director of The National Cancer Institute’s Office of Cancer Complementary and Alternative Medicine (OCCAM) invited Donato Perez Garcia, MD, Steven G. Ayre, MD, and Alan Dumoff, JD to attend and participate in conference on October 22-23 in Bethesda, MD. As per the email invitation from Dr. White, “Conference participants are encouraged to prepare poster presentations describing their cancer research or clinical practice. A portion of the second day of the conference will be set aside for presentations to promote discussion about specific issues relevant to furthering potential collaborations.” Dr. Ayre’s poster presentation will include updates on this QoL study and he will collaborate with other attendees to further progress on more detailed, clinical endpoint trials.