Articles and Publications
Publications and Essays on IPT
Insulin Potentiation Therapy: A Renaissance in Cancer Chemotherapy - How Does it Work? S.G. Ayre, MDPoster Presentation at the Third Annual Comprehensive Cancer Management Conference, Washington DC, June 2000
Hoist By One's Own Petard. S. G. Ayre, Townsend Letter, Oct. 1999.
Insulin Shows Promise. Oncology News, 1991, 17(4): 1,7
International Congress on Neo-Adjuvant Chemotherapy - Paris 1991
Neoadjuvant Low-Dose Chemotherapy with Insulin in Breast Carcinomas: S.G. Ayre, Perez-Garcia y Bellon, Perez-Garcia, Jr. European Journal of Cancer. 1990. 26(11-12): 1262-3.
Blood Brain Barrier Passage of Azidothyumidine in Rats: Effects of Insulin – S.G. Ayre, B. Skaletski, A.D. Mosnaim. Research Communications in Chemical Pathology and Pharmacology. Jan. 1989. Vol. 63, No. 1.
New Approaches to Delivery of Drugs to the Brain: S.G. Ayre. Medical Hypotheses 29:283-291, 1989.
IPT: A New Concept in the Management of Chronic Degenerative Disease: S.G. Ayre, D Perez Garcia y Bellon, D. Perez Garcia, Jr. Medical Hypotheses. 20(2): 199-210, 1986.
The Physiology and Clinical Pharmacology of Insulin in its Application in Insulin Potentiation Therapy (IPT): S.G. Ayre, MD
Low dose chemotherapy in combination with insulin for the treatment of metastatic tumors: C. Damyanov, M. Radoslavova, V. Gavrilov, D. Stoeva. Medical Center of Integrative Medicine, Sofia, Bulgaria. Journal of BUON 14: 711-15, 2009.
Insulin Potentiation Therapy in the treatment of malignant neoplastic diseases: a three year study: Ch. Damyanov, MD, PhD, D. Gerasimova, MD, D. Stoeva, MD, D. Dyukmedzhieva, MD. Medical Center of Integrative Medicine, Sofia, Bulgaria.
Supportive Studies - Published clinical and in-vitro studies that support the use of insulin as a biologic response modifier.
Metabolic Modification by Insulin Enhances Methotrexate Cytotoxicity in MCF-7 Human Breast Cells. Alabaster, O. Vonderhaar, B. and Shafie, S. Eur J Cancer Clin Oncol. Vol 17, No. 11, pp 1223-1228. 1961.
Insulin treatment in cancer cachexia: effects on survival, metabolism, and
physical functioning. Lundholm K, Körner U, Gunnebo L, Sixt-Ammilon P, Fouladiun M, Daneryd P, Bosaeus I. Clin Cancer Res. 2007 May 1;13(9):2699 706.
Long-Term Effect of Diabetes and Its Treatment on Cognitive Function. Jacobson, Alan, et.al. N Engl J Med 2007; 356:1842-52.
Preclinical safety and antitumor efficacy of insulin combined with irradiation. Bénédicte F. Jordan, Nelson Beghein, Nathalie Crokart, Christine Baudelet, Vincent Gregoire, Bernard Gallez. Radiotherapy and Oncology 81 (2006) 112–117.
Insulin-induced enhancement of antitumoral response to methotrexate in breast cancer patients. Lasalvio-Prisco, Eduardo, et.al. Cancer Chemother Pharmacol (2004) 53: 220–224.
The effect of insulin on chemotherapeutic drug sensitivity in human esophageal and lung cancer cells. Zhonghua Yi Xue Za Zhi. 2003 Feb 10;83(3):195-7.
Pretreatment with insulin enhances anticancer functions of 5-fluorouracil in human esophageal and colonic cancer cells. Zou K, Ju JH, Xie H. Acta Pharmacol Sin. 2007 May; 28(5):721-30.
Periodical Publications on Dr. Ayre and IPT
Chicago Magazine. The New Docs. January 2005.
A New Approach to Cancer Care - Middendorf, Bobbye. Conscious Choice. April 2001, Vol. 14 No. 4, 28-29.
Chitwood finds strength in physician's alternatives. Kendra L. Williams. Downers Grove Progress. Sept. 22, 2000.
Doctor to practice alternative methods for treating cancer - Kenneth Patchen. Antioch News. July 31, 1997. P A7.
Local Doctor develops treatments for cancer - Brian Murphy. Tom Tom (newspaper of Antioch Community High School, Antioch, IL). May 24, 1996
Doctor Researches Lifesaving Applications for an old drug. Mary Catherine Rhedin. Lakeland Newspapers, December 7, 1990. Pp 13-14.
History of IPT
A Brief History of IPT - Steven G. Ayre, MD
Chronology of Events in the Scientific Evaluation and Development of IPT
Documents of Historical Interest
- 1937 Austin State Hospital Pilot Study
- Comments of Mexican Military on IPT – Letter One - July 1, 1939
- Comments of Mexican Military on IPT - Letter Two - September 21, 1939
- Insulin For Everything – Time Magazine 1944
Personal Essays from Dr. Ayre
Managing Malignancy: Our Answer to Cancer
My Medical Opinion
Developing a Spirit of Achievement
Healing Ourselves
Prayer
Psychoneuroimmunology and the Future of Medicine. S.G. Ayre, Townsend Letter, Nov. 1988.
Let's Do Part to Cure Ills of Society. S.G. Ayre, American Medical News, Feb. 17, 1989.
MDs Must be Participants in Evolution of Medicine. S.G. Ayre, American Medical News, March 25, 1988.
Science Must Embrace Human Need. S.G. Ayre, American Medical News.
Too Bad Society Not Ready for Ideals. S. G. Ayre, American Medical News, Nov. 27, 1987.